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As we learn more about how it works, it could become an important tool for managing weight

1 Despite these constraints, the commercial consequence has been significant: Medicare logged $27.5 billion in gross GLP-1 spending across 21.8 million claims in 2024, entirely under FDA-approved indications other than obesity

The glucagon receptor activation increases metabolic rate, which can feel like a strange combination of tiredness and internal heat

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Furthermore, they carry a lower risk of hypoglycemia as they induce glucose-dependent insulin secretion.4,5 Their metabolism does not involve cytochrome P450 enzymes or transporter-mediated drugdrug interactions